Sabon Gwajin Hangzhou Ya Kaddamar da Sabon Samfurin Bincike na Dabbobin Epoch - Canine da Feline Renal Aiki 3-in-1 Kayan Gwaji
Hangzhou New-Test Biotechnology Co., Ltd. a hukumance ya ba da sanarwar ƙaddamar da sabbin samfuran bincike na zamani guda biyu zuwa kasuwar rigakafin rigakafin dabbobi ta duniya: Canine/Feline aikin koda sau uku Kit (Creatinine/SDMA/CysC Gwajin Sau uku) (Fig. 1 da Fig. 2), wanda ya kawo sabon kuma madaidaicin bayani ga binciken lafiyar dabbobi da magani.
Hoto 1 Kayan aikin koda na Canine kayan gwaji sau uku Hoto 2 Ayyukan koda na Feline na'urar gwaji sau uku
A cikin Oktoba 2022, New-Test Biotechnology Co., Ltd. shine farkon wanda ya fara ƙaddamar da na'urar nazari na multi-channel multix fluorescence immunoassay analyzer, NTIMM4 (ƙarni na uku, duba Hoto 3), kuma a cikin 2024, sabon tashar tashoshi guda ɗaya multix immunofluorescence. analyzer, NTIMM2 (ƙarni na huɗu, duba Hoto 4). Sabbin kayan aikin kit na gwangwani/na kashin 3-in-1 ya dace da nau'ikan duka biyun.
Hoto 3 NTIM4 Hoto 4 NTIMM2
Ƙwarewa a cikin ƙananan bincike da haɓakawa na ƙwayoyin ƙwayoyin cuta na tsawon shekaru shida, an ƙaddamar da sababbin samfurori.
Daidaiton gano ƙananan ƙwayoyin ƙwayoyin cuta ya kasance ƙalubale don shawo kan su a fagen gwajin POCT, kuma shi ne kuma jagorancin bincike da ci gaba wanda Nest-Test Bio ya sadaukar da shi tun lokacin da aka kafa shi fiye da shekaru 6 da suka wuce. Halayen kashe jiki da ruɓewar kayan kyalli na gargajiya kai tsaye suna shafar daidaiton ƙananan sakamakon gano kwayoyin halitta. Fasahar lakabin nanocrystal da ba kasafai ba, ƙarni na huɗu na nanomaterials mai kyalli na New-Test, an gane shi a matsayin mafi barga nanomaterials mai kyalli a kasuwa, wanda ke da fa'idar shawo kan halaye na zahiri na kashe haske. Haɗe tare da shekaru da yawa na ci gaba da inganta tsarin, a ƙarshe ya warware matsalar duniya na rashin daidaito a cikin ƙananan gwajin kwayoyin POCT. Turawa na farko shine kayan gwajin aikin koda sau uku. Yana ba da garantin daidaito da kwanciyar hankali na ƙananan ƙwayoyin ƙwayoyin cuta guda biyu (creatinine & SDMA) abubuwan ganowa a cikin lokacin ingancin shekaru 2.
"Hakanan akwai gwajin guda ɗaya, don haka me yasa haɓaka aikin koda triad”——Baya na haɓaka aikin koda triad
A halin yanzu, alamun gama gari na aikin koda mara kyau a cikin karnuka da kuliyoyi sun haɗa da creatinine (CREA) da urea nitrogen a cikin biochemistry; CysC (cystatin C) da kuma dimethylarginine symmetrical (SDMA) a cikin alamun rigakafi, da sauransu. A halin yanzu, an yi imani da cewa duk abubuwan da aka ambata a sama suna tace ta hanyar glomerulus. Lokacin da adadin tacewa na glomerular ya ragu saboda raunin koda, waɗannan alamun za su taru a cikin jini kuma suna karuwa a cikin taro, don haka suna nuna matakin rashin aiki na renal. Ƙungiyar International Society for Research in Kidney Diseases (IRIS) tsarin ƙididdige ƙididdiga ta rarraba raunin koda a cikin kuliyoyi zuwa maki hudu dangane da darajar creatinine (Grade I, al'ada ko m: <1.6 mg/dL; Grade II, matsakaici: 1.6-2.8 mg) /dL; Mataki na III, mai tsanani: 2.8-5.0 mg/dL; > 5.0 mg/dL).
An kasafta nakasa na koda a cikin karnuka zuwa maki hudu (Grade I, na al'ada ko m: <1.4 mg/dL: Grade II, matsakaici: 1.4-2.0 mg/dL: Grade III, mai tsanani: 2.0-4.0 mg/dL: Grade IV, da kuma matakin ƙarshe:> 4.0 mg/dL). Koyaya, saboda ƙarancin creatinine a cikin cututtukan koda na farko (CKD), an yi amfani da wani ma a baya mai nuna alamar aikin nephron, “symmetric dimethylarginine (SDMA)”,. Dangane da bayanan, SDMA na iya nuna rashin daidaituwa a 25-40% na nakasar koda, yayin da creatinine yawanci ana ɗaukarsa mara kyau a 75% na rashin ƙarfi.
CysC (cystatin C) shine mai hana protease na cysteine, ƙananan nauyin kwayoyin halitta (13.3 kD), furotin na asali marasa glycosylated. Yana daya daga cikin alamomin aikin koda na farko da aka fi amfani dashi a cikin maganin ɗan adam. Kamar creatinine da SDMA, ana tace shi ta cikin glomerulus, amma ya bambanta da creatinine da SDMA a cikin cewa metabolism ba ta hanyar urinary fili ba ne, amma kusan gaba ɗaya yana daidaita shi ta hanyar sake dawowa ta hanyar tubules na koda. ba a lura da shi a baya ba, yana jagorantar masana da yawa, masana da wallafe-wallafen zuwa yanke shawara guda biyu game da raunin koda na yau da kullum a cikin kuliyoyi: wasu sun yi imanin cewa CysC alama ce ta farko na ciwon koda na yau da kullum. Ana iya amfani da su a cikin karnuka da kuliyoyi, yayin da wasu sun yi imanin cewa CysC yana daidaitawa da kyau a cikin CKD na canine, amma mara kyau a cikin kuliyoyi.
Me yasa aka sami kishiyar ƙarshe guda biyu daga ma'anar aikin tacewa na glomerular?
Dalili kuwa shi ne Anuria, wanda wani yanayi ne da ya fi yaduwa a cikin kuraye fiye da sauran nau’in halittu, musamman a cikin kurayen maza. Wasu bayanai sun nuna cewa cutar Anuria a cikin kuliyoyi maza sun kai 68.6%, kuma Anuria zai haifar da toshewar fitar creatinine kai tsaye, urea nitrogen da SDMA. Kwayoyin kwayoyin suna ci gaba da haɓakawa da kuma samar da sababbin creatinine, urea nitrogen da SDMA, lokacin da aka gano dukkanin alamomi guda uku a cikin jini a wannan lokaci, za a sami karuwa mai girma ko ma fashewar alamomi ko da ko glomerulus ya lalace sosai.
CysC yana da ƙimar sa na musamman a wannan lokacin, kodayake wannan alamar ita ce tacewa ta glomerular, ba a daidaita shi ta hanyar fitsari ba, ta hanyar tubular ne don sake dawowa. Lokacin da Anuria ya faru amma aikin koda ya zama al'ada, ana iya kiyaye ma'anar CysC a matakin al'ada. Sai kawai lokacin da glomerulus ko lalacewar tubular ta faru, za a ɗaukaka ma'aunin CysC zuwa mara kyau. Saboda haka, gano duk ma'auni guda uku na iya yin ingantacciyar ganewar asali da samar da madaidaicin magani cikin sauri da inganci.
Sabbin gwajin aikin koda 3-in-1 kayan gwaji suna ba da sabon mahimmancin asibiti don gano raunin koda a cikin karnuka da kuliyoyi!
Bayanin ka'idoji da haɗuwa tare da halaye na masu nuna alama, an haifi sabbin kayan aikin renal na New-Test 3-in-1 tare da mahimman mahimmancin asibiti ga karnuka da kuliyoyi (musamman kuliyoyi) tare da Anuria:
Sabbin gwajin gwajin aikin koda 3-in-1 kayan gwaji ana amfani da su don bambance ko akwai ainihin raunin aikin koda a yanayin Anuria ko haifar da toshe haɓakar fihirisa saboda Anuria. Rauni na aikin koda na ainihi yana buƙatar kawai maganin catheterization na fitsari da kulawa mai alaƙa, kuma hasashen ya fi kyau gabaɗaya. The blockage daukaka na fihirisa bukatar ba kawai urinary catheterization da anti-mai kumburi magani, amma kuma alaka da magani tare da renal cuta, da kuma tsinkaya ne in mun gwada da matsala, kuma yana da matukar wuya a juya zuwa na kullum cutar koda.
Da ke ƙasa akwai alamar sabbin kayan aikin renal na gwajin gwaji na 3-in-1 don Anuria na yau da kullun (rauni mara kyau) da raunin koda Anuria + a cikin sabbin gwaje-gwajen bincike na asibiti:
| Gano Anuria Sabbin Gwaji aikin koda 3-in-1 kayan gwaji | Aikin | Sakamako | Sakamako |
| Creatin | + | + | |
| SDMA | + | + | |
| CysC | + | - | |
| Kammalawa | Anuria ya haifar da raunin koda | Matakin farko na Anuria da raunin koda ko Anuria wanda bai kai ga raunin koda ba |
A ƙasa akwai ɓangaren bayanan asibiti na yau da kullun da bayanin yanayin Sabbin Gwaji na aikin koda 3-in-1 kayan gwaji:
| Cat | Tarihin Likita | Alamar asibiti | CysC (mg/L) | SDHA (ug/dL) | CR (mg/dL) | Kammalawa |
| 2024090902 | Cystitis / Mummunan rauni na koda | Mummunan yanayin tunanin mutum, Rage cin abinci, Alamar koda mara kyau, Anuria (Rashin ciwon koda, anuria) | 1.09 | 86.47 | 8.18 | Raunin Renal tare da Anuria |
| 2024091201 | / | Mummunan yanayin tunani, Anuria, aikin koda mara kyau | 0.51 | 27.44 | 8.21 | Babu raunin koda tare da Anuria / Farkon mataki |
| 2024092702 | / | Anuri | 0.31 | > 100.00 | 9.04 | Babu raunin koda tare da Anuria / Farkon mataki |
| 2024103101 | / | Anuri | 0.3 | 14.11 | 6.52 | Babu raunin koda tare da Anuria / Farkon mataki |
| 2024112712 | Anuri | 0.5 | > 100.00 | 8.85 | Babu raunin koda tare da Anuria / Farkon mataki | |
| 2024112601 | Dysuria/Anuria | 0.43 | > 100.00 | 9.06 | Babu raunin koda tare da Anuria / Farkon mataki | |
| 0.47 | > 100.00 | 878 | Babu raunin koda tare da Anuria / Farkon mataki | |||
| 2024112712 | / | Anuri | 0.54 | 94.03 | 8.64 | Babu raunin koda tare da Anuria / Farkon mataki |
A cikin yanayin Anuria, saboda bambance-bambance a cikin tsarin rayuwa na ciki na kowane index, za a sami babban bambance-bambance don ma'aunin tace aikin koda. Saboda haka, rarrabuwa na al'ada na raunin koda na creatinine ko SDMA baya aiki, kuma ana iya samun ƙarshen ƙarshen asibiti kawai ta hanyar haɗa bincike tare da wani mai nuna "CysC". Ana ba da shawarar cewa dakunan gwaje-gwaje (asibitoci) su kafa ma'auni na ciki dangane da ƙwarewar asibiti, don bincika ƙarin sabbin mahimmancin asibiti.
A ƙarshe, New-Test Biotech yana fatan wannan labarin zai jefa bulo don jawo hankalin jed, kuma yana fatan ƙarin masana'antun likitancin dabbobi na kasar Sin da masana'antun sarrafa magunguna za su haɓaka ƙarin samfuran asibiti da kuma taimakawa ƙarin likitocin dabbobi na cikin gida don isa matakin farko a cikin aikin likitancin dabbobi. duniya!
Shafi: Karɓar Aikace-aikacen Haƙƙin mallaka don Kariyar Dukiya ta hankali
Lokacin aikawa: Janairu-22-2025
